NFL Week 1 : Preview on ReBet

The NFL season kicks off with a packed Week 1 slate, including a Thursday night rivalry game in Philadelphia and an international showcase in São Paulo. Using ReBet’s latest odds, here’s a breakdown of every matchup and the themes shaping the first week of the 2025 season.

Thursday, September 4

Dallas Cowboys (+8, +300) at Philadelphia Eagles (–8, –410) | O/U 47.5

The defending Super Bowl champions open against their NFC East rivals under the lights in South Philly. Philadelphia’s continuity has them as heavy favorites, but Dallas enters healthy and looking to prove they can keep pace. An 8-point spread makes this one of the more intriguing games of the week.

Friday, September 5 — International Game (São Paulo, Brazil)

Los Angeles Chargers (+138) vs. Kansas City Chiefs (–178) | O/U 46

Patrick Mahomes and Justin Herbert face off in Brazil in one of the NFL’s most high-profile divisional matchups. The Chiefs enter as favorites, but history suggests these two often play close games decided by a single score.

Sunday, September 7 — Early Slate

Cincinnati Bengals (–5, –240) at Cleveland Browns (+5, +174) | O/U 47.5

 A classic AFC North battle to open the year. Cincinnati’s offense is stacked, but Cleveland’s defense is capable of making this contest closer than the spread suggests.

Tampa Bay Buccaneers (–2.5, –145) at Atlanta Falcons (+2.5, +109) | O/U 47.5

An NFC South rivalry with little separation between the teams. Tampa Bay is narrowly favored, though Atlanta’s offense looks improved entering 2025.

Arizona Cardinals (–6.5, –330) at New Orleans Saints (+6.5, +228) | O/U 43

Arizona enters as one of Week 1’s biggest favorites despite playing on the road. The Saints still carry experience on defense, making this line notable for its size.

Las Vegas Raiders (+3, +119) at New England Patriots (–3, –158) | O/U 43.5

New England is favored at home, though both teams are working with fresh play-calling and offensive adjustments that could make this game unpredictable.

Pittsburgh Steelers (–3, –158) at New York Jets (+3, +119) | O/U 38.5

Oddsmakers expect a defensive battle here, reflected in one of the lowest totals of the week. Pittsburgh’s steady approach contrasts with New York’s younger roster still finding its footing.

New York Giants (+6.5, +210) at Washington Commanders (–6.5, –295) | O/U 45.5

The Giants look to bounce back against a Washington team that leans heavily on its defensive front. A near-touchdown spread makes this a key NFC East storyline.

Sunday, September 7 — Late Slate

Tennessee Titans (+8, +300) at Denver Broncos (–8, –461) | O/U 42.5

Denver is a big home favorite with altitude and roster experience on its side. Tennessee turns to rookie quarterback Cam Ward, who faces a tough opening test in Mile High.

Detroit Lions (+2.5, +111) at Green Bay Packers (–2.5, –148) | O/U 47

The NFC North rivalry continues with Green Bay slightly favored at home. Both teams bring balance on offense and physicality on defense, setting up one of the weekend’s closest matchups.

Primetime Games

Buffalo Bills at Baltimore Ravens

Two AFC contenders meet in one of Week 1’s most compelling matchups. Odds project this one as nearly even, with both teams capable of making early playoff statements.

Minnesota Vikings at Chicago Bears (Monday Night Football)

Week 1 closes in Chicago as the Bears host a divisional rival. Minnesota’s experienced skill players match up with a younger Chicago roster eager to prove itself under primetime lights.

Themes to Watch

1. Big Spreads Right Away - Philadelphia, Arizona, and Denver enter Week 1 as heavy favorites, each laying at least a touchdown on ReBet.

2. Division Rivalries Dominate - NFC East, AFC North, and NFC North rivalries highlight the schedule, often creating tighter games than expected.

3. Defensive Totals - Steelers–Jets and Cardinals–Saints carry low totals, suggesting defenses will dictate tempo.

4. Global Expansion - The Chiefs and Chargers meeting in Brazil marks a milestone for the NFL’s international schedule and delivers early-season fireworks.

   
   

Week 1 is always unpredictable, but ReBet’s lines highlight where oddsmakers see separation and where underdogs could surprise. From Philadelphia’s strong start to Denver’s altitude advantage and a Brazil showcase between AFC West rivals, the first week of the season sets the tone for the months ahead.